Is Flector Patch The Same As Fentanyl

The recommended dose of Flector Patch is one (1) patch to the most painful area twice a day. Flector Patch may interact with alcohol, other NSAIDs, blood thinners, cyclosporine, lithium, methotrexate, diuretics (water pills), steroids, or heart or blood pressure medications. FLECTOR® Patch is the only nonsteroidal anti-inflammatory (NSAID) patch that treats acute pain due to minor strains, sprains, and bruises. See risks & benefits.

Key points • Transdermal drug delivery offers pharmacokinetic and practical advantages over the oral or parenteral routes for some patients. • Patch design has important implications, for example, reservoir patches should never be cut whereas matrix patches can be trimmed. • Topical diclofenac is at least as effective as the oral form; it may be superior. • Development of a local subcutaneous drug reservoir beneath the patch means that buprenorphine and fentanyl patches require 24–72 h before the peak effect is achieved and there is delayed elimination after patch removal. • New technology to actively drive drug molecules through the transdermal barrier may reduce time to onset and allow patch delivery to be useful in the management of acute pain.

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Transdermal drug delivery is defined as the non-invasive delivery of medications through the skin surface. The use of analgesics as a ‘pain relief patch’ is gaining popularity. When applied to the skin, these patches can deliver an analgesic drug at a predetermined rate across the dermis to achieve either a local or systemic effect.

Transdermal delivery of medications is not a new concept. The use of transdermal delivery of homemade medicinal preparations dates to the early 20th century.

Mustard plasters were used for severe chest congestion. The Belladonna Plaster, containing 0.25% of Belladonna alkaloid, had a place in the US pharmacopeia as a transdermal analgesic. The success of nicotine patches nearly two decades ago revolutionized the use of transdermal drug delivery. Over the last decade, an increasing number of analgesic drugs have become available as transdermal patches. Patches offer advantages over conventional parenteral or oral routes.

They ensure controlled absorption and more uniform plasma drug concentrations. Bioavailability is improved by avoiding first-pass hepatic metabolism and enzymatic or pH-associated deactivation. Delivery of the drug is via a simple and painless application. There is increased flexibility in terminating drug administration by patch removal. Patient compliance is improved as patches are simple, non-invasive, and convenient. Clear labelling ensures rapid identification of medication. There are, however, some limitations to transdermal drug delivery.

First, there may be local irritation or sensitization of the skin at the site of patch application. Secondly, not all drugs are suitable for transdermal delivery. Thirdly, this modality is not suitable for shocked patients as decreased peripheral blood flow leads to unreliable transdermal absorption.

Finally, in comparison with other routes of drug delivery, the transdermal route is relatively more expensive. Pharmacokinetics of transdermal drug delivery The drug needs to be present in a high concentration within the patch for transdermal delivery to occur.

The energy for drug release is derived from the concentration gradient existing between a saturated solution of drug in the system and the much lower concentration in the skin; drug movement occurs by diffusion. Since there is a high concentration within the patch and a low concentration in the blood, the drug will continue to diffuse, maintaining a constant concentration of drug in the circulation. Where D is the diffusion coefficient, Co the constant concentration of drug in the patch, P the partition coefficient between the skin and bathing solution, and h the thickness of the skin. Transdermal permeation is improved if the drug has the following properties: • molecular weight. Components of the reservoir and matrix patches.

Several different types of transdermal patches are currently available: • Single-layer drug-in-adhesive patch: the adhesive layer adheres the various layers together and sticks the system to the skin; it is also responsible for releasing the drug. • Multi-layer drug-in-adhesive patch: both adhesive layers are responsible for release of the drug; one of the layers is for immediate release and the other layer is to control release of the drug from a reservoir.